Proto-oncogenes are normal genes into cells differentiate to share and participate. When these genes are mutated, are called oncogenes. Proto-oncogenes are involved in breast cancer, mainly due to increased cell division, so that the cell cycle, faster and faster. You are in the promotion of greater and more rapid cell division involved.
One of proto-oncogenes associated with the epidermal growth factor. This receptor plays an important role incertain times of the life cycle such as puberty, when the big changes happening with the growth of the body that a protein called epidermal growth factor stimulate cell growth are functions. This protein binds to a growth factor and epidermal growth signals from the cell. If the wait for the proto-oncogene receptor is over expressed, not for the epidermal growth factor, to tell him to grow. In contrast, the cells begin to grow independently, getting stuck in "ON" Position.
Another type of epidermal growth factor is a subtype of epidermal growth factor-2. This receptor is commonly known as HER-2/neu oncogene. The type of genetic modification, HER-2/neu in breast cancer is known to be amplified. Instead of a single copy in cell division, the cell produces many copies of this gene between ten and sixty times more. Or the expression of the gene or protein supplement can be measured in a womanCancer examine the tumor tissue was removed. Since the HER-2/neu oncogene encodes a growth factor receptor, which functions in signaling cells to grow faster and faster, although not involved in an invasive carcinoma. 70 to 80 percent of precancerous lesions of the breast is overexpress HER-2 / neu oncogene. breast cancer cells are still on the channel, but they are so programmed to grow much faster due to the expression of more thanOncogene such. Although HER-2/neu oncogene in breast cancer was the first site, the search will also be taken to determine if other forms of cancer such as lung, pancreatic and ovarian cancer are involved.
In the case of breast cancer are invasive, requires more than one genetic modification. Although there is only the expression of HER-2/neu oncogene, are breast cancer conducted will remain limited. If you use other forms ofgenetic mutations that cause cancer cells to leave the ductal region, or new blood vessels (angiogenesis), then it can spread. If the cancer is invasive cancer of these changes and the rapid growth of the cancer, then it is even worse. People with these genetic alterations have a worse prognosis of a single type of disorder alone. Cancer requires not only an excessive proliferation of tumor cells,They also won, grow new blood vessels and the spread of the breast.
One of the fascinating things that really happened in recent years is that now there is an antibody directed against HER-2/neu receptor, which counteract given intravenously in patients with breast cancer. Something a unique mechanism of action. The only cells with the HER-2/neu receptor is also not normal, so that while the cells antagonizes HER-2/neu, and without affecting other cells.Unlike chemotherapy, which destroys the majority of cases, cell division, is a targeted therapy. So far, this treatment was used only in metastatic breast cancer, but has implications for the disease is not yet widespread.
See Also : Department stores online Adult diapers stores Cheap Online Shopping Store Fertility clinic
rockpolaris